HORDB

ID: hor001844
Uniprot ID: Q69GG1
Protein name: Pea-FMRFa-22
Gene name: NA
Organism: Periplaneta americana (American cockroach) (Blatta americana)
Family: FARP (FMRFamide related peptide) family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Periplaneta (genus), Blattinae (subfamily), Blattidae (family), Blattoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: SGPSYDEKEQENEDGNSVRL
Length: 20
Propeptide: MGVGIIIAMHALFFFMYHIASSDVLDGTNTIDNVAALDISEDEDDCEPESSITSLPLKRAEEQNQPPPVRRRCSNRNFVRLGRGHDFDQDDVNSSGEKDESLVRIGRGGRSNDNFIRFGRGGKNDNFIRFGRGGKQDNFIRFGRDRSDNFIRFGRGKTDNFIRFGRGRSDNFIRFGRGKSDNFIRFGRARPDNFIRFGRGKQDFIRFGRGNSNFVRFGRDDSSNVETFDTEEEATTDSTLRVGRGGKSGSNFIRFGRARPSSNFIRLGRRDEEVTQREERGRPSNNFVRFGRQTEDDDKFVRLSRSGNSNELRRGKLTDRNFIRLGRSGPSYDEKEQENEDGNSVRLGRSENPSNSRNFIRLGKRALDQNLLVDEHLMRFGRDVEQIENTPVASSGEPSRSDTDNKTKENYQQSRSKRSISFSEEDSSEDSSDYPVMIPNSAYDDVKIPSPSVEDSQIPFRYYSPLSSGIPNYILGPELSVLPPLSNESKRGRGDGHNRNYIRLG
Signal peptide: MGVGIIIAMHALFFFMYHIASS
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Excitatory effects of antenna–heart;reduce the spike frequency of dorsal‐unpaired median neurons and reduce the intracellular calcium concentration
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001844_AF2.pdb

hor001844_ESM.pdb

Mass:	259234	Formula:	C91H141N27O40
Absent amino acids:	ACFHIMTW	Common amino acids:	E
pI:	3.84	Basic residues:	2
Polar residues:	8	Hydrophobic residues:	2
Hydrophobicity:	-190	Boman Index:	-8347
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	34
Instability Index:	5516.5	Extinction Coefficient cystines:	1490
Absorbance 280nm:	78.42

PubMed ID: 15355317
Title: Unique accumulation of neuropeptides in an insect: FMRFamide-related peptides in the cockroach, Periplaneta americana